Abstract

Research Article

Ocular surface Rose Bengal staining in normal dogs and dogs with Keratoconjunctivitis Sicca: Preliminary findings

Williams DL* and Griffiths A

Published: 30 October, 2017 | Volume 1 - Issue 1 | Pages: 042-046

Dry eye or keratoconjunctivitis sicca, is commonly seen in the dog. Veterinary ophthalmologists diagnose this aqueous tear deficiency using the Schirmer tear test (STT), but this measures tear production and does not indicate ocular surface pathology. The vital dye Rose Bengal is commonly used in the diagnosis of dry eye in human patients but until now has not been reported in veterinary patients. Here we corelate the degree of Rose Bengal staining with the STT value and find a reasonable association between dye staining of the ocular surface and tear production, although clearly other factors are also important in the genesis of ocular surface damage in dry eye.

Read Full Article HTML DOI: 10.29328/journal.ivs.1001005 Cite this Article Read Full Article PDF

References

  1. Williams DL. Immunopathogenesis of keratoconjunctivitis sicca in the dog. Vet Clin North Am Small Anim Pract. 2008; 38: 251-268. Ref.: https://goo.gl/rJZUPb  
  2. Schirmer O. Studien zur physiologie und pathologie der tränenabsonderung und tränenabfuhr. Graefe's Archive for Clinical and Experimental Ophthalmology. 1903; 56: 197-291. Ref.: https://goo.gl/W458V6
  3. Gelatt KN, Peiffer RL Jr, Erickson JL, Gum GG. Evaluation of tear formation in the dog, using a modification of the Schirmer tear test. J Am Vet Med Assoc. 1975; 166: 368-370. Ref.: https://goo.gl/aokwK2
  4. Sjogren H. Zur kenntnis der keratoconjunctivitis sicca (keratitis filiformis bei hypofunktiondder tranendrusen. Acta Ophthalmol. 1933; 86: 36-39. Ref.: https://goo.gl/WuTzG8
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  6. Norn MS. Specific double vital staining of the cornea and conjunctiva with Rose Bengal and Alcian Blue. Acta Ophthalmol (Copenh). 1964; 42: 84-96. Ref.: https://goo.gl/bSfUbB
  7. Norn MS. Vital staining of the cornea and conjunctiva; with a mixture of fluorescein and rose bengal. Am J Ophthalmol. 1967; 64: 1078-1080. Ref.: https://goo.gl/wYVdSM
  8. Norn MS. Rose Bengal vital staining. Staining of cornea and conjunctiva by 10 percent rose bengal, compared with 1 percent. Acta Ophthalmol (Copenh). 1970; 48: 546-559. Ref.: https://goo.gl/axJAVQ
  9. Feenstra RP, Tseng SC. What is actually stained by rose bengal? Arch Ophthalmol. 1992; 110: 984-993. Ref.: https://goo.gl/YJ7t6Q
  10. Williams DL, Buckingham A. Measurement of tear osmolarity in the canine eye: a new diagnostic tool for canine keratoconjunctivitis sicca? J Vet Sci. 2017; 3: 8-12. Ref.: https://goo.gl/3MpFks
  11. Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, et al. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997; 104: 223-235. Ref.: https://goo.gl/s5kxZE
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