Abstract

Research Article

Influence of Vitamin E on the Disposition Kinetics of Florfenicol after single and multiple oral administrations in Broiler Chickens

Fatma Ibrahim Abo El-Ela*, Hossny Awad El-Banna, Manal B El-Deen and Tohamy MA

Published: 12 December, 2017 | Volume 1 - Issue 1 | Pages: 047-057

Investigation the influences of vitamin (vit) E over a period of 5 days on the pharmacokinetics of florfenicol after single and multiple oral administrations in broiler chickens. Total of 12 broiler chickens had been taken single and multiple oral administrations of florfenicol (30 mg/kg) alone or pre-treated with vit E (2 mg/kg). The serum concentrations of florfenicol were determined using microbiological assay with Bacillus subtilis (ATCC 25922) as a tested microorganism. The mean serum concentrations of florfenicol alone were markedly lower when compared with florfenicol pre-treated with vit E after single and multiple dosing. The peak serum concentrations (Cmax) were 5.9±0.46, 7.48±0.3 ug/ml, absorption half-life (t0.5ab) of 0.51±0.06, 0.71±0.1 h and elimination half-life (t0.5el) of 2.72±0.34, 3.34±0.5 after single florfenicol alone and florfenicol pre-treated with vit E respectively. While, after multiple dosing, (Cmax) were 7.4±0.3, 8.04±0.3 ug/ml, (t0.5ab) 0.82±0.04, 0.81±0.04 h and (t0.5 el) 3.77±0.2, 4.52±0.7 h after multiple dosing of florfenicol alone and florfenicol pre-treated with vit E respectively. In conclusion Vit E alter the disposition kinetics of florfenicol after single and multiple oral administrations as, vit E allows prolongation of the duration of action for more 24 and 48 h of the drug concentration in the serum indicated by prolonged elimination half-lives and MRT reflecting the importance of this combination for the drug duration in serum but the increase in the serum concentration of florfenicol increasing its efficacy not toxicity as florfenicol of wide safety margin so, it’s advisable for poultry farms owners to use this combinations.

Read Full Article HTML DOI: 10.29328/journal.ivs.1001006 Cite this Article Read Full Article PDF

Keywords:

Florfenicol; Vit E; Single; Multiple; Pharmacokinetics; Broilers

References

  1. Lis M, Szczypka M, Suszko A, Świtala M, Obminska-mrukowicz B. The effects of florfenicol on lymphocyte subsets and humoral immune response in mice. Polish J Vet Sci. 2011; 14: 191-198. Ref.: https://goo.gl/sPnJbh
  2. Papich MG, Riviere JE. Chloramphenicol and derivatives, macrolides, lincosamides and miscellaneous antimicrobials. Vet Pharmacol and Therap Iowa State and miscellaneous antimicrobials. 2011; 868-897.
  3. Koc F, Ozturk M, Kadioglu Y, Dogan E, Yanmaz LE, et al. Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand white rabbits. Res Vet Sci. 2009; 87: 102-105. Ref.: https://goo.gl/qV6jKy
  4. Holmes K, Bedenice D, Papich MG. Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection. J Vet Pharmacol Ther. 2012; 35: 382-388. Ref.: https://goo.gl/31FhQo
  5. Chang SK, Davis JL, Cheng CN, Shien RH, Heleh MK, et al. Pharmacokinetics and tissue depletion of florfenicol in Leghorn and Taiwan Native chickens. J Vet Pharmacol Therap. 2010; 33: 471-479. Ref.: https://goo.gl/kCir38
  6. Edwards DJ. Beneficial Pharmacokinetic Drug Interactions. Adv Pharmacoepidem Drug Safety. 2012; S1: 2.
  7. Daniel E, Becker DDS. Adverse Drug Interactions. Anesth Prog. 2011; 58: 31-41.
  8. Hegerova E, imunek J. Influence of coccidiostats on the pharmacokinetics of orally administered sulphonamides. 4th Congress of the EAVPT. 1988; 66.
  9. Lashev L. Pharmacokinetics of apramycin and sulpha-chlor pyridazine co-administered with flavor-phospholipol and avoparcin to chickens. Bulg J Vet Med. 1998; 1: 71-76. Ref.: https://goo.gl/AafE4X
  10. Moutafchieva R. Effects of some nutritive antibiotics on the pharmacokinetics of tylosin in chickens. Vet sbirka(Bg). 1989; 3: 19-22.
  11. Ramadan A, Hanafy MS, Afifi NA. Effect of pantotenic acid on disposition kinetics and tissue residues of sulphadimidine in chickens. Res Vet Sci. 1992; 52: 337-341. Ref.: https://goo.gl/aDnPQK
  12. Sharmanov T. Ascorbic acid. In: Experimentally vitaminology. (Ostrovski, U., Ed.), Minsk, Science and Technology. 1979; 481-500.
  13. Maliha SS, Shahed MJ, Janker MN, Abasi KW, Nigm-Rahman AE. Clinical and experimental evidences in antibiotics side effects and toxicity associate with overdose and long-term of use. Pharmacol Assoc J. 2009; 6: 23-31.
  14. Velanganni AJ, Balasundaram C. Protective effect of vitamin A, ascorbic acid and α-tocopherol on 2,4- dimethylaminoazobenzene-induced hepatoma in rats. Current Sci. 2003; 85: 201- 203. Ref.: https://goo.gl/vh8jwu
  15. Ukpanukpong RU, Eteng MU, Dasofunj OK. Antioxidant interactions of Pefloxacin, garlic, vitamins C and E on lipid profile level of albino wistar rats. J App Pharm Sci. 2013; 3: 167-170. Ref.: https://goo.gl/c9hNve
  16. Afifi NA, Abo El-Sooud KA. Tissue concentrations and pharmacokinetics of florfenicol in broiler chickens. Brt Poult Sci. 1997; 38: 425-428. Ref.: https://goo.gl/2fHnvM
  17. Abd El-Aty AM, Goudah A, Abo El-Sooud K, El-Zorba HY, Shimoda M, et al. pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administration in rabbits. Vet Res Commun. 2004; 28: 515-524. Ref.: https://goo.gl/rwkDnj
  18. Craig AW, Suh B. Protein binding and the antibacterial effects. Method for the determination of protein binding. In: Lorain, V.(Ed.). Antibiotics in Laboratory Medicine. 1991; 367-402.
  19. Sendecor GW, Cochran WG. Statistical methods. 7th Ed. The Iowa State University, Press Ames, Iowa, USA. 1981.
  20. Dingfei H, Jianzhong S, Xianai W. Pharmacokinetics of florfenicol in Broiler Chickens. Acta Vet et Zootech Sinica. 2002; 33: 384-388. Ref.: https://goo.gl/wKNGKf
  21. El-Banna HA, El-Zorba HY. Pharmacokinetics of florfenicol (Water soluble formulation) in healthy 21 and Pasteurella infected broiler chickens. World Rur Obs. 2011; 1: 13-19. Ref.: https://goo.gl/ScfDQS
  22. Shen J, Wu X, Hu D. Pharmacokinetics of florfenicol in healthy and Escherichia-coliinfected broiler chickens. Res vet sci. 2002; 37: 137-140. Ref.: https://goo.gl/4TwZsn
  23. Shen J, Hu D, Wu X. Bioavailability and pharmacokinetics of florfenicol in broiler chickens. J Vet Pharmacol Ther. 2003; 26: 337-341. Ref.: https://goo.gl/wKmBNf
  24. Tohamy MA, Radi AM. Bioavilability and pharmacokinetics of Florfenicol in healthy foals. J Egypt Soc Pharmacol Exp Ther. 2008; 29: 529-538.
  25. Abu-Basha EAH, Gehring R, Al-Shunnaq AF.Pharmacokinetics and Bioequivalence of florfenicol Oral Solution Formulations (Flonicol® and Veterin®10%) in Broiler Chickens. J Bioequiv Availab. 2012; 4: 1-5.
  26. El-hadjela D, Zine K, Leila B. The beneficial effect of combined administration of vitamins C and E on renal function and selected parameters of antioxidant system in diabetic rats fed zinc-deficient diet. Africa J Biotech. 2013; 12: 6232-6240. Ref.: https://goo.gl/JqkwQg
  27. Haritova AM, Lashev LD. Pharmacokinetics of olendamycin administered alone and after oral ascorbic acid in three bird species. Veterinarski Arhiv. 2003; 73: 199-210. Ref.: https://goo.gl/F3Tkwm
  28. Yang Q, Xie L, Wu Z. Pharmacokinetics of florfenicol after oral administration in yellow catfish, Pelteobagrus fulvidraco. J World Aquacul Soc. 2013; 44: 586-592. Ref.: https://goo.gl/LdPFjQ
  29. Giroud A, Leblond CP. Histological study of renal elimination of ascorbic acid. Anat Rec. 1973; 68: 113. Ref.: https://goo.gl/EofjN8
  30. Ralli EP, Friednan GJ, Rubin SH. The mechanism of vitamin C by the human kidney. J Clin Invest.1938; 17: 765-770. Ref.: https://goo.gl/Fq5a7z
  31. Attia HF, Soliman MM, Ismail TH. Protective Effect of Vitamin E and Selenium on the liver, heart and aorta. J Vet Anat. 2012; 5: 17-29. Ref.: https://goo.gl/5vhvzL
  32. Uboh FE, Ebong BK, Akpan HD, et al. Hepatoprotective effect of vitamins C and E against gasoline vapor-induced liver injury in male rats. Turk J Biol. 2012; 36: 217-223. Ref.: https://goo.gl/beZLMs
  33. Liu J, Fung K, Chen Z, Zeng Z, Zhang J. Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae. Antimicrob agents Chemother. 2003; 47: 820-823. Ref.: https://goo.gl/tNKQvP

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More